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Organocatalytic, Enantioselective Conjugate Addition of Nitroalkanes to Nitroolefins
Author(s) -
Wang Jian,
Li Hao,
Zu Liansuo,
Jiang Wei,
Wang Wei
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600247
Subject(s) - enantioselective synthesis , cinchona , chemistry , conjugate , organocatalysis , cinchona alkaloids , organic chemistry , michael reaction , catalysis , combinatorial chemistry , mathematical analysis , mathematics
An organocatalytic, enantioselective conjugate addition reaction of nitroalkanes with nitroolefins has been developed under neat conditions without using an organic solvent. The process, catalyzed by a modified Cinchona alkaloid, affords synthetically useful 1,3‐dinitro compounds in good yields (70–82 %) with good degrees of enantioselectivity (67–88 % ee ).
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