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Lewis Acid‐Catalyzed Direct Amination of Benzhydryl Alcohols
Author(s) -
Terrasson Vincent,
Marque Sylvain,
Georgy Marie,
Campagne JeanMarc,
Prim Damien
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200600236
Subject(s) - chemistry , amination , lewis acids and bases , catalysis , amine gas treating , yield (engineering) , organic chemistry , filtration (mathematics) , combinatorial chemistry , materials science , metallurgy , statistics , mathematics
The Lewis acid‐mediated direct amination of benzylic alcohols is described, providing various benzylic amine derivatives in good yields under mild and environmentally benign conditions. Among the different Lewis acids tested, gold(III) proved to be the catalyst of choice for both chemical (yield, conversion) and practical reasons (a filtration over a silica pad is generally sufficient to obtain the corresponding benzylic amine in analytically pure form).