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A One‐Pot Enantioselective Chemo‐Enzymatic Synthesis of Amino Acids in Water
Author(s) -
Simons Chrétien,
Hanefeld Ulf,
Arends Isabel W. C. E.,
Maschmeyer Thomas,
Sheldon Roger A.
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505395
Subject(s) - chemistry , enantioselective synthesis , hydrolysis , catalysis , enzyme , enzymatic hydrolysis , amino acid , biocatalysis , organic chemistry , enzyme catalysis , compatibility (geochemistry) , combinatorial chemistry , biochemistry , ionic liquid , chemical engineering , engineering
The combination of immobilised Rh‐MonoPhos ( 1 ‐AlTUD‐1) and acylase I afforded a chemo‐enzymatic, one‐pot process for the enantioselective synthesis of amino acids in water, without the need for isolation of intermediates. In addition, the enzymatic hydrolysis increases the enantiopurity of the product from 95% ee to >98% ee. Compatibility studies revealed that for optimum results compartmentalisation of the catalysts is required.