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Mild Conditions for Copper‐Catalyzed Coupling Reaction of Phenols and Aryl Iodides and Bromides
Author(s) -
Ouali Armelle,
Spindler JeanFrancis,
Cristau HenriJean,
Taillefer Marc
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505385
Subject(s) - chemistry , aryl , catalysis , phenols , copper , iodide , coupling reaction , ligand (biochemistry) , combinatorial chemistry , base (topology) , organic chemistry , alkyl , mathematical analysis , biochemistry , receptor , mathematics
Coupling of phenols and aryl bromides can be efficiently performed by means of catalytic amounts of copper iodide and the inexpensive ligand 1 (structure given in Table 1). The reaction is applicable to a wide range of substrates and proceeds at 60–80 °C, the lowest temperatures reported to date for an Ullmann‐type synthesis of diaryl ethers. Moreover, the use of aryl bromides and inexpensive K 3 PO 4 as base make this method attractive for applications on an industrial scale.
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