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An Efficient Approach to Chiral Ferrocene‐Based Secondary Alcohols via Asymmetric Hydrogenation of Ferrocenyl Ketones
Author(s) -
Lam WingSze,
Kok Stanton H. L.,
AuYeung Terry T.L.,
Wu Jing,
Cheung HongYee,
Lam FukLoi,
Yeung ChiHung,
Chan Albert S. C.
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505321
Subject(s) - chemistry , ferrocene , asymmetric hydrogenation , ruthenium , enantioselective synthesis , noyori asymmetric hydrogenation , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , electrochemistry , electrode
P‐Phos‐ruthenium‐DPEN precatalysts have been found to be efficient for the asymmetric hydrogenation of various ferrocenyl ketones. The use of ( R )‐xylyl‐P‐PhosRuCl 2 ( R , R )‐DPEN generated chiral ferrocenylethanol in 99.3% e.e. with >99% conversion in a 150‐g scale.
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