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A Very Simple Synthesis of Chloroalkenes and Chlorodienes by Selective Suzuki Couplings of 1,1‐ and 1,2‐Dichloroethylene
Author(s) -
Barluenga José,
Moriel Patricia,
Aznar Fernando,
Valdés Carlos
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505302
Subject(s) - chemistry , simple (philosophy) , suzuki reaction , combinatorial chemistry , coupling reaction , reaction conditions , coupling (piping) , computational chemistry , organic chemistry , catalysis , palladium , mechanical engineering , philosophy , epistemology , engineering
Chloroalkenes, important building blocks for cross‐coupling reactions, are prepared in one step by the Suzuki reaction of 1,1‐dichloroethylene and 1,2‐dichloroethylene with alkenyl‐ and arylboronic acids. Under the proper reaction conditions, it is possible to obtain the monocoupling reaction to provide the corresponding chloroalkenes with good yields. This method represents an excellent route for the preparation of chloroalkenes and chlorodienes from commercially available starting materials.