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Isomerization of Propargylic Alcohols into α,β‐Unsaturated Carbonyl Compounds Catalyzed by the Sixteen‐Electron Allyl‐Ruthenium(II) Complex [Ru(η 3 ‐2‐C 3 H 4 Me)(CO)(dppf)][SbF 6 ]
Author(s) -
Cadierno Victorio,
GarcíaGarrido Sergio E.,
Gimeno José
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505294
Subject(s) - ruthenium , isomerization , chemistry , regioselectivity , catalysis , medicinal chemistry , conjugated system , allyl alcohol , organic chemistry , polymer
The 16‐e − (η 3 ‐allyl)‐ruthenium(II) complex [Ru(η 3 ‐2‐C 3 H 4 Me)(CO)(dppf)][SbF 6 ] is an efficient catalyst for the regioselective isomerization of terminal propargylic alcohols HCCCR 1 R 2 (OH) into α,β‐unsaturated aldehydes R 1 R 2 CCHCHO or ketones R 3 R 4 CC(R 1 )COMe (if R 2 =CHR 3 R 4 ) under mild conditions. This complex has been also used as catalyst for the preparation of conjugated 1,3‐enynes via dehydration of propargylic alcohols.