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Ru‐(Phosphine‐Oxazoline) Complexes as Effective, Industrially Viable Catalysts for the Enantioselective Hydrogenation of Aryl Ketones
Author(s) -
Naud Frédéric,
Malan Christophe,
Spindler Felix,
Rüggeberg Carsten,
Schmidt Andreas T.,
Blaser HansUlrich
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505246
Subject(s) - oxazoline , chemistry , acetophenone , phosphine , aryl , catalysis , enantioselective synthesis , noyori asymmetric hydrogenation , substrate (aquarium) , organic chemistry , asymmetric hydrogenation , combinatorial chemistry , medicinal chemistry , alkyl , oceanography , geology
Complexes prepared in situ from RuCl 2 (PPh 3 ) 3 and chiral phosphine‐oxazoline ligands are effective catalysts for the hydrogenation of various aryl ketones with ees up to 99% and substrate to catalyst ratios of 10,000–50,000; the reaction tolerates high substrate concentrations and a pilot process has been developed for the hydrogenation of 3,5‐bistrifluoromethyl acetophenone.