Ru‐(Phosphine‐Oxazoline) Complexes as Effective, Industrially Viable Catalysts for the Enantioselective Hydrogenation of Aryl Ketones | Zendy

Naud Frédéric | Zendy; Malan Christophe | Zendy; Spindler Felix | Zendy; Rüggeberg Carsten | Zendy; Schmidt Andreas T. | Zendy; Blaser HansUlrich | Zendy

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Ru‐(Phosphine‐Oxazoline) Complexes as Effective, Industrially Viable Catalysts for the Enantioselective Hydrogenation of Aryl Ketones

Author(s) -

Naud Frédéric,

Malan Christophe,

Spindler Felix,

Rüggeberg Carsten,

Schmidt Andreas T.,

Blaser HansUlrich

Publication year - 2006

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200505246

Subject(s) - oxazoline , chemistry , acetophenone , phosphine , aryl , catalysis , enantioselective synthesis , noyori asymmetric hydrogenation , substrate (aquarium) , organic chemistry , asymmetric hydrogenation , combinatorial chemistry , medicinal chemistry , alkyl , oceanography , geology

Complexes prepared in situ from RuCl 2 (PPh 3 ) 3 and chiral phosphine‐oxazoline ligands are effective catalysts for the hydrogenation of various aryl ketones with ees up to 99% and substrate to catalyst ratios of 10,000–50,000; the reaction tolerates high substrate concentrations and a pilot process has been developed for the hydrogenation of 3,5‐bistrifluoromethyl acetophenone.

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