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Highly Air‐ and Water‐Stable Fluorinated Ferrocenylphosphine‐Aminophosphine Ligands and their Applications in Asymmetric Hydrogenations
Author(s) -
Li Xingshu,
Jia Xian,
Xu Lijin,
Kok Stanton H. L.,
Yip C. W.,
Chan Albert S. C.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505241
Subject(s) - chemistry , catalysis , combinatorial chemistry , organic chemistry
Air‐ and water‐stable fluorinated ferrocenylphosphine‐aminophosphine ligands have been synthesized and applied to the Rh‐catalyzed asymmetric hydrogenation of enamides and α‐dehydroamino acid derivatives. These reactions afforded the corresponding products in good to excellent ees (up to 99.7% ee) and nearly quantitative yields. The combination of the remarkable air‐ and water‐stability with excellent catalytic performance makes these catalysts excellent choices for practical applications.