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A Selective Transformation of Flavanones to 3‐Bromoflavones and Flavones Under Microwave Irradiation
Author(s) -
Zhou Zhongzhen,
Zhao Peiliang,
Huang Wei,
Yang Guangfu
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505223
Subject(s) - flavones , chemistry , flavanone , microwave irradiation , catalysis , microwave , organic chemistry , flavonoid , combinatorial chemistry , chromatography , physics , quantum mechanics , antioxidant
This paper presents the first report of a highly selective transformation of flavanones to 3‐bromoflavones or flavones by microwave irradiation of the corresponding flavanone reactants and N ‐bromosuccinimide (NBS) in the presence of a catalytic amount of 2,2′‐azobis(isobutyronitrile) (AIBN). The combination of good to excellent yields, shorter reaction time (10 min), and high levels of functional group compatibility make this an attractive synthetic approach to 3‐bromoflavones and flavones.