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Pd‐Catalyzed ortho ‐Selective Oxidative Coupling of Halogenated Acetanilides with Acrylates
Author(s) -
Lee George T.,
Jiang Xinglong,
Prasad Kapa,
Repič Oljan,
Blacklock Thomas J.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505202
Subject(s) - acetanilide , chemistry , catalysis , substituent , oxidative coupling of methane , substrate (aquarium) , halogen , medicinal chemistry , oxidative phosphorylation , photochemistry , coupling (piping) , organic chemistry , biochemistry , oceanography , alkyl , geology , mechanical engineering , engineering
Coupling of different halogenated acetanilides with acrylates using Pd‐catalyzed ortho ‐selective CH bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron‐rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions