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New Carbohydrate‐Based Phosphite‐Oxazoline Ligands as Highly Versatile Ligands for Palladium‐Catalyzed Allylic Substitution Reactions
Author(s) -
Mata Yvette,
Diéguez Montserrat,
Pàmies Oscar,
Claver Carmen
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505192
Subject(s) - chemistry , allylic rearrangement , oxazoline , catalysis , palladium , steric effects , ligand (biochemistry) , substitution reaction , substitution (logic) , combinatorial chemistry , tsuji–trost reaction , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , computer science , programming language
We have designed and synthesized a new family of readily available phosphite‐oxazoline ligands for Pd‐catalyzed asymmetric allylic substitution reactions. These ligands can be tuned in two regions to explore their effect on catalytic performance. By carefully selecting the ligand components, we obtained high enantioselectivities in the Pd‐catalyzed allylic substitution in substrates with different steric properties