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A New Method for the Generation of Titanium(III) Complexes and its Application in Pinacol Coupling Reactions
Author(s) -
Knoop Christoph Alexander,
Studer Armido
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505180
Subject(s) - pinacol , chemistry , homolysis , titanium , benzaldehyde , coupling (piping) , tin , reductive elimination , radical , combinatorial chemistry , photochemistry , medicinal chemistry , organic chemistry , computational chemistry , catalysis , metallurgy , materials science
A new method for the in situ generation of various Ti(III) complexes is presented. Cyclohexadienyl‐Ti(IV) derivatives, which are readily prepared from the corresponding lithiated cyclohexadienes, afford the corresponding Ti(III) complexes upon thermal CTi‐bond homolysis. The Ti(III) compounds generated using this novel method have successfully been used in the reductive dimerization of benzaldehyde. In particular, TiBr 3 , TiCp 2 Cl and Ti(O‐ i‐ Pr) 3 have been generated via this approach. Moreover, the method also offers an entry to new chiral Ti(III) complexes as documented by the preparation of Ti(III)CpTADDOLate.