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Industrial‐Scale Palladium‐Catalyzed Coupling of Aryl Halides and Amines –A Personal Account
Author(s) -
Buchwald Stephen L.,
Mauger Christelle,
Mignani Gerard,
Scholz Ulrich
Publication year - 2006
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505158
Subject(s) - chemistry , aryl , halide , palladium , catalysis , ligand (biochemistry) , scale (ratio) , combinatorial chemistry , coupling (piping) , coupling reaction , organic chemistry , mechanical engineering , biochemistry , alkyl , receptor , physics , quantum mechanics , engineering
The palladium‐catalyzed coupling of amines and aryl halides or aryl alcohol derivatives has matured from an exotic small‐scale transformation into a very general, efficient and robust reaction during the last ten years. This article reports several applications of this method from an industrial vantage point, including ligand synthesis, synthesis of arylpiperazines, arylhydrazines and diarylamines. Much emphasis in placed on issues of scale‐up and safety to underline the potential of CN couplings as solutions for industrial‐scale synthetic problems.