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Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1 R ,2 R )‐2‐(Dimethylamino)‐ 1,2‐diphenylethanol
Author(s) -
Yamashita Mitsuaki,
Yamada Kenichi,
Tomioka Kiyoshi
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505157
Subject(s) - chemistry , alkynylation , catalysis , trifluoromethanesulfonate , toluene , enantiomeric excess , enantioselective synthesis , medicinal chemistry , zinc , enantiomer , terminal (telecommunication) , aldehyde , organic chemistry , telecommunications , computer science
Catalytic asymmetric alkynylation of aldehydes with terminal alkynes was catalyzed by zinc triflate and (1 R ,2 R )‐2‐(dimethylamino)‐1,2‐diphenylethanol in toluene to give the corresponding alcohols with high enantiomeric excess up to 98% in good yields.