Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1 R ,2 R )‐2‐(Dimethylamino)‐ 1,2‐diphenylethanol | Zendy

Yamashita Mitsuaki | Zendy; Yamada Kenichi | Zendy; Tomioka Kiyoshi | Zendy

Premium

Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1 R ,2 R )‐2‐(Dimethylamino)‐ 1,2‐diphenylethanol

Author(s) -

Yamashita Mitsuaki,

Yamada Kenichi,

Tomioka Kiyoshi

Publication year - 2005

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200505157

Subject(s) - chemistry , alkynylation , catalysis , trifluoromethanesulfonate , toluene , enantiomeric excess , enantioselective synthesis , medicinal chemistry , zinc , enantiomer , terminal (telecommunication) , aldehyde , organic chemistry , telecommunications , computer science

Catalytic asymmetric alkynylation of aldehydes with terminal alkynes was catalyzed by zinc triflate and (1 R ,2 R )‐2‐(dimethylamino)‐1,2‐diphenylethanol in toluene to give the corresponding alcohols with high enantiomeric excess up to 98% in good yields.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research