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Cross–Coupling Reactions of Allylic Alcohols in Water
Author(s) -
Manabe Kei,
Nakada Kenji,
Aoyama Naohiro,
Kobayashi Shū
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505135
Subject(s) - chemistry , allylic rearrangement , catalysis , base (topology) , coupling reaction , palladium , coupling (piping) , organic chemistry , medicinal chemistry , mechanical engineering , mathematical analysis , mathematics , engineering
Palladium–catalyzed cross–coupling reactions of allylic alcohols and arylboronic acids in water are described. The reactions proceeded smoothly in water at reflux using catalytic amounts of [Pd(allyl)Cl] 2 and PPh 3 . Addition of a catalytic amount of a base allowed the reaction to proceed even at lower temperatures.