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New Trends in Palladium‐Catalyzed Transfer Hydrogenations Using Formic Acid
Author(s) -
Prasad Kapa,
Jiang Xinglong,
Slade Joel S.,
Clemens Jennifer,
Repič Oljan,
Blacklock Thomas J.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505132
Subject(s) - formic acid , chemistry , ammonium formate , catalysis , formate , ammonia , palladium , substrate (aquarium) , carbon dioxide , transfer hydrogenation , organic chemistry , organic base , inorganic chemistry , ruthenium , oceanography , geology
In the presence of a catalytic amount of organic bases, Pd‐catalyzed transfer hydrogenations with formic acid were found to be facile processes. These new conditions produce innocuous carbon dioxide as the by‐product compared to the use of ammonium formate, which generates ammonia and carbon dioxide as gaseous by‐products which recombine to create unsafe conditions. When the substrate is basic enough to form salts with formic acid, no additional base is necessary. In certain cases, the product of the reaction was used to accelerate the transfer hydrogenation process.