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Rhodium‐BisbenzodioxanPhos Complex‐Catalyzed Homogeneous Enantioselective Pauson–Khand‐Type Cyclization in Alcoholic Solvents
Author(s) -
Kwong Fuk Yee,
Lee Hang Wai,
Qiu Liqin,
Lam Wai Har,
Li YueMing,
Kwong Hoi Lun,
Chan Albert S. C.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505105
Subject(s) - enantioselective synthesis , chemistry , decarbonylation , rhodium , pauson–khand reaction , enantiomer , aldehyde , catalysis , homogeneous , ligand (biochemistry) , bicyclic molecule , combinatorial chemistry , stereochemistry , organic chemistry , receptor , biochemistry , physics , thermodynamics
The chiral atropisomeric diphosphane ligand ( S )‐BisbenzodioxanPhos was found to be highly effective in the co‐operative processeses of aldehyde decarbonylation and cascaded enantioselective Pauson–Khand‐type reactions. Various 1,6‐enynes were transformed to the corresponding bicyclic cyclopentenones in good yields and enantiomeric excesses (up to 96% ee). The attractive feature of this new Rh‐catalyzed homogeneous dual catalysis system is that the reaction can be performed in alcoholic solution.