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A High‐Throughput Screening Approach for the Determination of Additive Effects in Organozinc Addition Reactions to Aldehydes
Author(s) -
Rudolph Jens,
Lormann Matthias,
Bolm Carsten,
Dahmen Stefan
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505090
Subject(s) - chemistry , reagent , aldehyde , substrate (aquarium) , high throughput screening , throughput , ligand (biochemistry) , combinatorial chemistry , catalysis , chiral ligand , organic chemistry , enantioselective synthesis , computer science , telecommunications , biochemistry , oceanography , receptor , wireless , geology
The effects of additives in phenylzinc addition reactions to an aldehyde have been studied using an automated high‐throughput screening approach. With 2‐bromobenzaldehyde as test substrate and N , N ‐dibutylnorephedrine (dbne) as chiral ligand, an improvement of 20% ee over the catalyzed reaction in the absence of the additive was observed. The described results enable a novel access towards chiral diarylmethanols using commercially available substrates, reagents and ligands as well as fast, automated techniques.