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Asymmetric Aldol Reaction Using Immobilized Proline on Mesoporous Support
Author(s) -
Calderón Félix,
Fernández Raquel,
Sánchez Félix,
FernándezMayoralas Alfonso
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200505058
Subject(s) - aldol reaction , chemistry , proline , catalysis , stereoselectivity , mesoporous material , homogeneous , heterogeneous catalysis , organocatalysis , organic chemistry , enantioselective synthesis , mcm 41 , combinatorial chemistry , amino acid , biochemistry , physics , thermodynamics
The aldol reaction of hydroxyacetone with different aldehydes using immobilized proline on a mesoporous support, assisted by heat and microwaves, has been explored. It was found that heterogenized L ‐proline on MCM‐41 catalyzed aldol reactions in both hydrophilic and hydrophobic solvents, and provided stereoselectivities in some cases complementary to the homogeneous catalyst. The heterogeneous catalysts could be reused without significant lost of stereoselectivity.