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Rhodium‐Catalyzed Asymmetric Pauson–Khand Reaction Using Monophosphoramidite Ligand SIPHOS
Author(s) -
Fan BaoMin,
Xie JianHua,
Li Shen,
Tu YongQiang,
Zhou QiLin
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404395
Subject(s) - chemistry , rhodium , pauson–khand reaction , intramolecular force , catalysis , ligand (biochemistry) , carbonylation , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , carbon monoxide , receptor , biochemistry
A novel rhodium‐catalyzed asymmetric intramolecular Pauson–Khand reaction using a chiral monophosphoramidite ligands is described. In this reaction, an in situ generated catalyst from [Rh(CO) 2 Cl] 2 , the spiro‐monophosphoramidite ligand SIPHOS and AgSbF 6 was found to be effective for a series of 1,6‐enynes, providing the co‐cyclization products in good enantioselectivities (84% ee).
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