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The Synthesis of Important Pharmaceutical Building Blocks by Palladium‐Catalyzed Coupling Reaction: Access to Various Arylhydrazines
Author(s) -
Mauger Christelle,
Mignani Gérard
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404392
Subject(s) - chemistry , benzophenone , palladium , halide , aryl , catalysis , hydrazone , coupling reaction , combinatorial chemistry , coupling (piping) , organic chemistry , alkyl , mechanical engineering , engineering
Various arylhydrazones have been successfully synthesized via a highly efficient palladium‐catalyzed cross‐coupling reaction between aryl halides and benzophenone hydrazone. All the reaction parameters have been studied and coupling products were obtained with excellent yields from the corresponding bromides or chlorides.