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Homologation of Monoterpenoids into New Sesquiterpenoids via Tandem Isomerisation/Claisen Rearrangement Reactions with Three‐Component Ruthenium Catalysts, and Ru(methallyl) 2 (COD) Revealed by High Throughput Screening Techniques
Author(s) -
Le Nôtre Jérôme,
Touzani Rachid,
Lavastre Olivier,
Bruneau Christian,
Dixneuf Pierre H.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404391
Subject(s) - chemistry , ruthenium , isomerization , catalysis , tandem , claisen rearrangement , ligand (biochemistry) , reagent , aldehyde , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , materials science , receptor , composite material
Abstract A catalytic system B based on a ruthenium source Ru 3 (CO) 12 , a bulky imidazolinium salt and Cs 2 CO 3 appears very efficient for the transformation of a 1,7‐diene into a γ,δ‐unsaturated aldehyde via tandem isomerisation/Claisen reactions. 1,6‐Dienes arising from the terpenoids menthone and myrtenal were selectively transformed into the corresponding unsaturated aldehydes with catalyst B . High throughput experiments were undertaken to evaluate other multicomponent catalysts: metal source/ligand/base for these tandem reactions. An unexpected catalyst was found to be Ru(methallyl) 2 (COD) which can operate without additional ligand or reagent.