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Efficient and Scalable Protocol for the Z ‐Selective Synthesis of Unsaturated Esters by HornerWadsworthEmmons Olefination
Author(s) -
Touchard François P.,
Capelle Nicolas,
Mercier Mathilde
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404338
Subject(s) - chemistry , reagent , organic chemistry
The synthesis of a highly Z ‐selective Horner–WadsworthEmmons (HWE) reagent from cheap and readily available starting materials on a 200‐g scale is described. The HWE reaction conditions have also been studied in order to design an efficient and scalable protocol leading to Z ‐selectivities close to 95% with aromatic and aliphatic aldehydes.