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Rhodium‐Catalyzed, Three‐Component Reaction of Diazo Compounds with Amines and Azodicarboxylates
Author(s) -
Huang Haoxi,
Wang Yuanhua,
Chen Zhiyong,
Hu Wenhao
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404306
Subject(s) - chemistry , diazo , aminal , catalysis , rhodium , selectivity , ammonium , ammonium acetate , medicinal chemistry , organic chemistry , component (thermodynamics) , high performance liquid chromatography , physics , thermodynamics
A novel, three‐component CN bond forming reaction is described. Reaction of diazo compounds with both azodicarboxylates and arylamines in the presence of dirhodium acetate catalyst gives good yields of the corresponding aminal with high selectivity and, in most cases, NH insertion side products were suppressed. This is the first example of a CN bond formation from the addition of ammonium ylides to azodicarboxylates.