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Enantioselective Alkynylation of Aromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands
Author(s) -
Kang YongFeng,
Liu Lei,
Wang Rui,
Zhou YiFeng,
Yan WenJin
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404278
Subject(s) - enantioselective synthesis , chemistry , oxazolidine , phenylacetylene , alkynylation , catalysis , organic chemistry , combinatorial chemistry
New chiral oxazolidine ligands have been derived conveniently from natural amino acids in good yields. Their use in the enantioselective addition of phenylacetylene to aromatic ketones has been tested with the best ee being up to 88%. We provide a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.