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Efficient Synthesis of Lactate‐Containing Depsipeptides by the Mitsunobu Reaction of Lactates
Author(s) -
Grab Tobias,
Bräse Stefan
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404252
Subject(s) - depsipeptide , chemistry , mitsunobu reaction , combinatorial chemistry , stereochemistry
The Mitsunobu reaction has been used as an efficient tool for the synthesis of orthogonally‐protected and unprotected depsipeptides such as Boc/Fmoc‐ L ‐Lys(Alloc)‐ D ‐Ala‐ D ‐Lac‐OAllyl or L ‐Lys‐ D ‐Ala‐ D ‐Lac that are bacterial cell wall precursor analogues found in vancomycin‐resistant enterococci.
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