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The Development of Enantioselective Rhodium‐Catalysed Hydroboration of Olefins
Author(s) -
Carroll AnneMarie,
O'Sullivan Timothy P.,
Guiry Patrick J.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404232
Subject(s) - hydroboration , enantioselective synthesis , chemistry , rhodium , borane , denticity , catalysis , organic chemistry , combinatorial chemistry , metal
Rhodium‐catalysed enantioselective hydroboration of olefins is a valuable synthetic transformation, typically employing a chiral catalyst and an achiral borane source. The pertinent chemo‐, regio‐ and enantioselectivity issues of this reaction are discussed. However, the main emphasis of this review is on the evolution of catalytic asymmetric hydroboration. This has primarily relied upon the development and application of chiral bidentate P,P and P,N ligands which have exhibited varying degrees of success in this transformation.