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Nickel‐Catalyzed Cross‐Couplings of Unactivated Alkyl Halides and Pseudohalides with Organometallic Compounds
Author(s) -
Netherton Matthew R.,
Fu Gregory C.
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404223
Subject(s) - chemistry , halide , alkyl , nickel , electrophile , catalysis , reagent , organometallic chemistry , group 2 organometallic chemistry , hydrogen , combinatorial chemistry , organic chemistry , molecule
Until recently, there had been a widespread perception that unactivated, β‐hydrogen‐containing alkyl halides/pseudohalides are not suitable partners for nickel‐catalyzed coupling reactions. During the past several years, a number of reports have dispelled this misconception by demonstrating that a diverse array of electrophiles and organometallic reagents can in fact be efficiently cross‐coupled.