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Palladium‐Catalyzed CN and CO Coupling–A Practical Guide from an Industrial Vantage Point †
Author(s) -
Schlummer Björn,
Scholz Ulrich
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404216
Subject(s) - chemistry , palladium , amination , catalysis , aryl , halide , coupling reaction , scale (ratio) , field (mathematics) , nanotechnology , organic chemistry , biochemical engineering , combinatorial chemistry , physics , engineering , materials science , mathematics , pure mathematics , alkyl , quantum mechanics
The palladium‐catalyzed coupling of amines with aryl halides or aryl alcohol derivatives, commonly dubbed Buchwald–Hartwig amination, has matured from a synthetic laboratory procedure to a technique that is widely used in natural product synthesis as well as in other fields of academic interest. Furthermore, due to the versatility and reliability of this reaction, researchers in industrial environments have included this methodology in their toolbox as a standard procedure for the synthesis of amine derivatives. Therefore, it is not surprising that first industrial processes up to ton‐scale have been performed using this cross‐coupling reaction. The authors who are involved in the application of this reaction to industrial processes on this scale give an overview of the recent developments in this field of chemistry, also including fundamental principles, with a special focus on the industrial approach and issues to be considered relevant in scaling‐up this transition metal‐catalyzed chemistry. This review differs from the already existing excellent academic reviews by focusing on the practical problems arising during implementing the methodology in an industrial environment as well as giving practical hints to this end.