Premium
Monolithic Disk‐Supported Metathesis Catalysts for Use in Combinatorial Chemistry
Author(s) -
Mayr Monika,
Wang Dongren,
Kröll Roswitha,
Schuler Norbert,
Prühs Stefan,
Fürstner Alois,
Buchmeiser Michael R.
Publication year - 2005
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404197
Subject(s) - metathesis , romp , desymmetrization , chemistry , ring opening metathesis polymerisation , catalysis , salt metathesis reaction , polymerization , polymer chemistry , medicinal chemistry , organic chemistry , enantioselective synthesis , polymer
Two metathesis catalysts, RuCl 2 (PCy 3 )(NHC)(CHPh) ( 1 ) [NHC=1‐(2,4,5‐trimethylphenyl)‐3‐(6‐hydroxyhexyl)‐imidazol‐2‐ylidene] and Mo(N‐2,6‐ i‐ Pr 2 ‐C 6 H 3 )(CHCMe 2 Ph)(BIPHEN) ( 2 ) [BIPHEN=( R )‐3,3′‐di‐ t‐ butyl‐5,5′,6,6′‐tetramethyl‐2,2′‐biphenolate) have been immobilized on polymeric, monolithic discs using a “grafting from” protocol. Monolithic discs were prepared via ring‐opening metathesis polymerization (ROMP) from norborn‐2‐ene (NBE), tris(norborn‐5‐ene‐2‐ylmethyleneoxy)methylsilane [(NBE‐CH 2 O) 3 ‐SiCH 3 ], 2‐propanol, toluene and RuCl 2 (PCy 3 ) 2 (CHPh). Catalyst loadings of 0.55 and 0.7 wt %, respectively, were obtained. Monolithic disc‐immobilized 1 was used in various metathesis‐based reactions including ring‐closing metathesis (RCM), ring‐opening cross metathesis and enyne metathesis. Using 0.23–0.59 mol % of supported 1 , turnover numbers (TONs) up to 330 were achieved. Monolithic disc‐immobilized 2 was used in various enantioselective RCM and desymmetrization reactions. Using 9–13 mol % of supported catalyst, excellent yields up to 100% and high enantiomeric excess (ee≤88%) were observed. In both cases, metal leaching was low (≤3 and ≤2%, respectively). In addition, 1 catalyzed the cyclopolymerization of diethyl dipropargylmalonate (DEDPM) to yield poly(ene)s consisting of 5‐membered rings, i.e., cyclopent‐1‐ene‐1‐vinylene units. The polymerization proceeded via non‐stoichiometric initiation yielding polymers with unimodal molecular weight distribution. Using a catalyst to monomer ratio of 1 : 170, molecular weights of M w =16,400 and M n =11,700 g/mol, PDI=1.40 were obtained.