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A Domino Copper‐Catalyzed CN and CO Cross‐Coupling for the Conversion of Primary Amides into Benzoxazoles
Author(s) -
Altenhoff Gereon,
Glorius Frank
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404182
Subject(s) - chemistry , domino , catalysis , regioselectivity , yield (engineering) , copper , primary (astronomy) , cascade reaction , combinatorial chemistry , medicinal chemistry , coupling reaction , coupling (piping) , organic chemistry , metallurgy , materials science , physics , astronomy
Benzoxazoles can be efficiently prepared in a single step and in good yield from primary amides and o ‐dihalobenzenes using Cu catalysis. Starting from substituted o ‐bromochlorobenzenes this unusual domino reaction allows the regioselective formation of benzoxazoles.