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A Novel Thiourea Ligand Applied in the Pd‐Catalyzed Heck, Suzuki and Suzuki Carbonylative Reactions
Author(s) -
Mingji Dai,
Liang Bo,
Wang Cuihua,
You Zejin,
Xiang Jing,
Dong Guangbin,
Chen Jiahua,
Yang Zhen
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404165
Subject(s) - chemistry , thiourea , suzuki reaction , phosphine , palladium , catalysis , ligand (biochemistry) , steric effects , heck reaction , organic chemistry , carbonylation , combinatorial chemistry , polymer chemistry , medicinal chemistry , carbon monoxide , biochemistry , receptor
A novel C 2 symmetrical and sterically bulky thiourea ligand 1 has been successfully applied to Heck, Suzuki and Suzuki‐type carbonylative coupling reactions under aerobic conditions. Since the metal‐sulfur bond in the thiourea complexes is stronger than the metal‐phosphorus bond of typical phosphine complexes, thiourea ligands generally do not easily dissociate from the metal center under catalytic conditions, which establishes the thiourea 1 ‐based palladium complexes as effective catalysts for the palladium‐catalyzed cross‐coupling reactions.
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