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Industrial R&D on Catalytic CC and CN Coupling Reactions: A Personal Account on Goals, Approaches and Results
Author(s) -
Blaser HansUlrich,
Indolese Adriano,
Naud Frédéric,
Nettekoven Ulrike,
Schnyder Anita
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404156
Subject(s) - chemistry , catalysis , coupling (piping) , coupling reaction , principal (computer security) , combinatorial chemistry , organic chemistry , biochemical engineering , computer science , engineering , mechanical engineering , operating system
R&D issues for the application of Pd‐ and Ni‐catalyzed CC and CN coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of CC and CN coupling for preparative applications is described. The following principal approaches to industrial research are illustrated with relevant examples from the literature and from our own laboratories: i) development of catalysts and catalytic methodologies with industrial potential; ii) finding shorter routes to target molecules using catalytic methods; iii) development of industrial catalytic processes in multi‐step syntheses.