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Palladium‐Catalyzed Desulfitative Sonogashira–Hagihara Cross‐Couplings of Arenesulfonyl Chlorides and Terminal Alkynes
Author(s) -
Reddy Dubbaka Srinivas,
Vogel Pierre
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404146
Subject(s) - chemistry , catalysis , sonogashira coupling , palladium , aryl , medicinal chemistry , terminal (telecommunication) , organic chemistry , telecommunications , alkyl , computer science
For the first time, conditions have been found for the palladium‐catalyzed desulfitative carbon‐carbon cross‐coupling of arenesulfonyl chlorides with aryl‐ and alkylacetylenes. Pd 2 (dba) 3 /P( t ‐Bu) 3 and CuI provide the best catalyst for reactions in refluxing THF and in the presence of K 2 CO 3 .