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Stetter Reaction in Room Temperature Ionic Liquids and Application to the Synthesis of Haloperidol
Author(s) -
Anjaiah Siddam,
Chandrasekhar Srivari,
Grée René
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404123
Subject(s) - ionic liquid , chemistry , catalysis , solvent , ionic bonding , haloperidol , organic chemistry , combinatorial chemistry , inorganic chemistry , ion , neuroscience , biology , dopamine
Imidazolium‐type room temperature ionic liquids (RTILs) have been used for the Stetter reaction, affording the desired 1,4‐dicarbonyl compounds in good yields. Thiazolium salts and Et 3 N are efficient catalysts for this reaction performed in ionic liquid. The possibility to recycle and reuse the solvent has been demonstrated, although it was not possible to recycle the thiazolium catalyst. This method was used in the total synthesis of haloperidol.