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Scale‐Up Studies for the Asymmetric Juliá–Colonna Epoxidation Reaction
Author(s) -
Gerlach Arne,
Geller Thomas
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200404079
Subject(s) - chemistry , ketone , substrate (aquarium) , yield (engineering) , catalysis , reaction conditions , epoxy , impeller , scale (ratio) , combinatorial chemistry , organic chemistry , thermodynamics , oceanography , physics , quantum mechanics , geology
The asymmetric Juliá–Colonna epoxidation reaction under triphasic/PTC conditions has been successfully scaled‐up to a one‐hundred gram substrate level providing the corresponding epoxy ketone with high optical purity (up to 97% ee) and in good yield (75–78%). The amount of polyamino acid catalyst could be reduced leading to a simplified reaction work‐up. In order to minimise the overall reaction time baffled reactors with pitched‐blade impellers have been employed.