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Iridium‐Catalyzed Enantioselective Hydrogenation of Olefins
Author(s) -
Pfaltz Andreas,
Blankenstein Jörg,
Hilgraf Robert,
Hörmann Esther,
McIntyre Steven,
Menges Frederik,
Schönleber Marc,
Smidt Sebastian P.,
Wüstenberg Bettina,
Zimmermann Nicole
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200390027
Subject(s) - chemistry , iridium , enantioselective synthesis , rhodium , phosphine , asymmetric hydrogenation , ruthenium , catalysis , cationic polymerization , medicinal chemistry , trifluoromethyl , noyori asymmetric hydrogenation , boron , organic chemistry , counterion , ion , alkyl
Cationic iridium complexes with chiral P,N‐ligands and tetrakis[3,5‐(trifluoromethyl)phenyl]borate (BAr F ) as the counterion are efficient homogeneous catalysts for the enantioselective hydrogenation of olefins. The complexes are readily prepared, air‐stable, and easy to handle. In contrast to chiral rhodium‐ and ruthenium‐phosphine catalysts, they do not require the presence of a polar coordinating group near the CC bond. In the hydrogenation of unfunctionalized arylolefins, high enantioselectivities of >95% ee with turnover numbers of up to 5000 and turnover frequencies of >5000 h −1 have been achieved.