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High Throughput Kinetic Investigations of Asymmetric Hydrogenations with Microdevices
Author(s) -
de Bellefon C.,
Pestre N.,
Lamouille T.,
Grenouillet P.,
Hessel V.
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200390010
Subject(s) - chemistry , kinetic energy , catalysis , rhodium , throughput , liquid phase , aqueous solution , gas phase , chemical engineering , organic chemistry , combinatorial chemistry , nanotechnology , thermodynamics , telecommunications , physics , quantum mechanics , computer science , engineering , wireless , materials science
A high throughput test which is based on a micromachined mixer for molecular gas‐liquid reactions was evaluated for the kinetic investigation of the asymmetric hydrogenation of methyl Z‐(α)‐acetamidocinamate with a rhodium/( S,S ‐BDPPTS) catalyst in an aqueous phase. Up to 214 tests were performed in a short time and with an average inventory of Rh/test as low as 14 μg. Comparisons with traditional batch experiments are provided.