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Bicyclic O,P Ligands for Catalytic Asymmetric 1,4‐Addition to α ,β ‐Unsaturated Ketones
Author(s) -
Modin Stefan A.,
Pinho Pedro,
Andersson Pher G.
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303238
Subject(s) - bicyclic molecule , chemistry , reagent , ligand (biochemistry) , catalysis , ketone , cyclohexenone , medicinal chemistry , enone , combinatorial chemistry , organic chemistry , receptor , biochemistry
A new class of bicyclic O,P ligands has been prepared and evaluated in the 1,4‐addition to α ,β ‐unsaturated ketones. The best results with the bicyclic ligand were obtained using a lower catalyst loading than what has been reported with similar ligands when adding a Grignard reagent to 2‐cyclohexenone.