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Direct Reductive Amination versus Hydrogenation of Intermediates –A Comparison
Author(s) -
Tararov Vitali I.,
Kadyrov Renat,
Riermeier Thomas H.,
Fischer Christine,
Börner Armin
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303208
Subject(s) - reductive amination , chemistry , acetophenone , enamine , benzylamine , imine , piperidine , amination , enantioselective synthesis , catalysis , organic chemistry , combinatorial chemistry , asymmetric hydrogenation
Abstract The direct reductive amination of acetophenone with benzylamine or piperidine was studied in comparison with the hydrogenation of possible intermediates like a corresponding imine or enamine. No common features in terms of productivity and stereocontrol (in the case of chiral catalysts) have been found for both processes. Hence evaluation of efficient, selective and enantioselective catalysts for direct reductive amination appears to be a separate task.