Premium
Hypervalent Iodine Reagents for the Oxidation of Alcohols and Their Application to Complex Molecule Synthesis
Author(s) -
Tohma Hirofumi,
Kita Yasuyuki
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303203
Subject(s) - hypervalent molecule , chemistry , chemoselectivity , iodine , reagent , organic chemistry , reactivity (psychology) , alcohol oxidation , combinatorial chemistry , alcohol , catalysis , medicine , alternative medicine , pathology
Hypervalent iodine(V) derivatives such as 2‐iodoxybenzoic acid (IBX) and Dess–Martin periodinane [DMP; 1,1,1‐tris(acetyloxy)‐1,1‐dihydro‐1,2‐benziodoxol‐3‐(1 H )‐one] have been used widely for the oxidation of alcohols to aldehydes and ketones during the last decade because of their high chemoselectivity, mild reactivity, and high yielding process. This review focuses on the recent progress in the oxidation of alcohols to carbonyl compounds using IBX, DMP, and other hypervalent iodine reagents, and their application to total syntheses of a variety of complex natural products.