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IBX‐Mediated Conversion of Primary Alcohols and Aldehydes to N ‐Hydroxysuccinimide Esters
Author(s) -
Schulze Agnes,
Giannis Athanassios
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303195
Subject(s) - chemistry , hypervalent molecule , primary (astronomy) , reagent , organic chemistry , iodine , aldehyde , alcohol oxidation , oxide , combinatorial chemistry , alcohol , catalysis , astronomy , physics
Recently, the use of the hypervalent iodine reagent 1‐hydroxy‐1,2‐benziodoxol‐3(1 H )‐one 1‐oxide (IBX) for the oxidation of primary alcohols and aldehydes to carboxylic acids was described. During the synthesis of these carboxylic acids the corresponding N ‐hydroxysuccinimide esters were formed as intermediate products, but their isolation as main reaction products was not successful. We report herein a simple and very efficient method to prepare these synthetically valuable active esters.