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Biomimetic Chemical Catalysts in the Oxidative Activation of Drugs
Author(s) -
Bernadou Jean,
Meunier Bernard
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303191
Subject(s) - chemistry , oxidative phosphorylation , catalysis , cytochrome p450 , oxidative metabolism , in vivo , combinatorial chemistry , drug , pharmacology , biochemistry , metabolism , microbiology and biotechnology , medicine , biology
An overview of the biomimetic catalysts used in the oxidative activation of drugs is given, with an emphasis on the use of synthetic metalloporphyrins as models of cytochrome P450 to mimic the in vivo metabolism of pharmaceuticals. In addition, a special focus is directed towards the recent results from the authors' group on the oxidative activation of isoniazid, an antitubercular drug.