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The Resolution of Important Pharmaceutical Building Blocks by Palladium‐Catalyzed Aerobic Oxidation of Secondary Alcohols
Author(s) -
Caspi Daniel D.,
Ebner David C.,
Bagdanoff Jeffrey T.,
Stoltz Brian M.
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303188
Subject(s) - chemistry , kinetic resolution , palladium , catalysis , enantioselective synthesis , combinatorial chemistry , organic chemistry
The palladium‐catalyzed aerobic oxidative kinetic resolution of key pharmaceutical building blocks is described. Substrates investigated are relevant to the enantioselective preparation of Prozac ® , Singulair ® , and the promising hNK‐1 receptor antagonist from Merck. The latter provides the most selective aerobic oxidative kinetic resolution yet described.