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Cyclodextrins or Calixarenes: What is the Best Mass Transfer Promoter for Suzuki Cross‐Coupling Reactions in Water?
Author(s) -
Hapiot F.,
Lyskawa J.,
Bricout H.,
Tilloy S.,
Monflier E.
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303149
Subject(s) - phenylboronic acid , suzuki reaction , calixarene , chemistry , palladium , coupling reaction , coupling (piping) , aqueous solution , aqueous medium , combinatorial chemistry , polymer chemistry , organic chemistry , molecule , materials science , catalysis , metallurgy
Cyclodextrins or calixarenes possessing extended hydrophobic host cavities and surface‐active properties were found to be very efficient as mass transfer promoters for the palladium‐mediated Suzuki cross‐coupling reaction of 1‐iodo‐4‐phenylbenzene and phenylboronic acid in aqueous medium. The cross‐coupling rates were up to 92 times higher than those obtained without addition of any compound.