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The Development of Bidentate P,N Ligands for Asymmetric Catalysis
Author(s) -
Guiry Patrick J.,
Saunders Cormac P.
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303138
Subject(s) - chemistry , hydroboration , denticity , catalysis , enantioselective synthesis , rhodium , palladium , ligand (biochemistry) , allylic rearrangement , metal , combinatorial chemistry , stereochemistry , tsuji–trost reaction , medicinal chemistry , organic chemistry , biochemistry , receptor
In this review, an attempt is made to systemise the rôle which bidentate phosphinamine (P,N) ligands play in asymmetric catalysis. The ligands will be classified, not by the reaction to which their metal complexes have been applied, but by the nature of their donor atoms. In this manner the development of ligand architectural design can be more easily monitored. The asymmetric transformations to which metal complexes of these ligands have been applied include among others, palladium‐catalysed allylic substitutions, copper‐catalysed 1,4‐additions to enones and rhodium‐catalysed hydroboration of vinylarenes. Excellent enantioselectivities, regioselectivities and reactivities have been achieved in each of these processes.