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Gold(III) Chloride‐Catalyzed Addition Reactions of Electron‐Rich Arenes to Methyl Vinyl Ketone
Author(s) -
Dyker Gerald,
Muth Enrico,
Hashmi A. Stephen K.,
Ding Li
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303098
Subject(s) - chemistry , catalysis , friedel–crafts reaction , methyl vinyl ketone , steric effects , ketone , chloride , vinyl chloride , medicinal chemistry , organic chemistry , photochemistry , copolymer , polymer
For the reaction of α,β‐unsaturated ketones with electron‐rich arenes catalyzed by gold(III) chloride both, a Friedel–Crafts‐type mechanism and an initial metallation, are evaluated. Gold(III) chloride has proven to be an efficient catalyst under very moderate reaction conditions, however, in the case of sterically demanding products HBF 4 turned out to be the superior catalyst.