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Combinatorial Design of Copper‐Based Mixed Nanoclusters: New Catalysts for Suzuki Cross‐Coupling
Author(s) -
Thathagar Mehul B.,
Beckers Jurriaan,
Rothenberg Gadi
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303045
Subject(s) - chemistry , nanoclusters , copper , suzuki reaction , substituent , catalysis , cluster (spacecraft) , palladium , combinatorial chemistry , photochemistry , organic chemistry , computer science , programming language
Quantum dots (2–5 nm) of copper and copper/palladium mixtures are found to be good catalysts for Suzuki cross‐coupling. The catalysts are applicable to a wide range of iodo‐ and bromoaryl substrates, and give moderate yields using chloroaryl substrates. Cluster activity and stability is found to depend strongly on the preparation method and the reaction conditions. The mechanism of cluster deactivation and the sensitivity of the cluster‐catalysed reaction to substituent effects are studied and discussed.