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The Catalytic Asymmetric Addition of Diethylzinc to N ‐(Diphenylphosphinoyl) Imines Catalyzed by Cu(OTf) 2 ‐Chiral N ‐(Binaphthyl‐2‐yl)thiophosphoramide Ligands
Author(s) -
Shi Min,
Wang ChunJiang
Publication year - 2003
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303041
Subject(s) - diethylzinc , chemistry , catalysis , medicinal chemistry , ligand (biochemistry) , diamine , enantioselective synthesis , addition reaction , stereochemistry , organic chemistry , biochemistry , receptor
Chiral N ‐(binaphthyl‐2‐yl)thiophosphoramide L7 [ O,O ‐diethyl 2′‐(ethylamino)‐1,1′‐binaphthyl‐2‐ylamidothiophosphate] prepared from the reaction of diethyl chlorothiophosphate with ( R )‐(+)‐ N ‐ethyl‐1,1′‐binaphthyl‐2,2′‐diamine was used as a catalytic chiral ligand in the first Cu(OTf) 2 ‐promoted catalytic asymmetric addition of diethylzinc to N ‐(diphenylphosphinoyl) imines in which ~85% ee can be realized.