The Catalytic Asymmetric Addition of Diethylzinc to  N ‐(Diphenylphosphinoyl) Imines Catalyzed by Cu(OTf) 2 ‐Chiral  N ‐(Binaphthyl‐2‐yl)thiophosphoramide Ligands | Zendy

Shi Min | Zendy; Wang ChunJiang | Zendy

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The Catalytic Asymmetric Addition of Diethylzinc to N ‐(Diphenylphosphinoyl) Imines Catalyzed by Cu(OTf) 2 ‐Chiral N ‐(Binaphthyl‐2‐yl)thiophosphoramide Ligands

Author(s) -

Shi Min,

Wang ChunJiang

Publication year - 2003

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200303041

Subject(s) - diethylzinc , chemistry , catalysis , medicinal chemistry , ligand (biochemistry) , diamine , enantioselective synthesis , addition reaction , stereochemistry , organic chemistry , biochemistry , receptor

Chiral N ‐(binaphthyl‐2‐yl)thiophosphoramide L7 [ O,O ‐diethyl 2′‐(ethylamino)‐1,1′‐binaphthyl‐2‐ylamidothiophosphate] prepared from the reaction of diethyl chlorothiophosphate with ( R )‐(+)‐ N ‐ethyl‐1,1′‐binaphthyl‐2,2′‐diamine was used as a catalytic chiral ligand in the first Cu(OTf) 2 ‐promoted catalytic asymmetric addition of diethylzinc to N ‐(diphenylphosphinoyl) imines in which ~85% ee can be realized.

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